2019 Nobel Medicine Prize: Three scientists receive it for learning how cells use oxygen

The work by the three laureates has “greatly expanded our knowledge of how physiological response makes life possible," Nobel Committee says.

William G. Kaelin, Jr, Peter J. Ratcliffe and Gregg L. Semenza. Image Source: BBC
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Monday (October 7): The 2019 Nobel Prize for Physiology or Medicine has been awarded to scientists William G. Kaelin, Jr, Peter J. Ratcliffe and Gregg L. Semenza.

The prize was awarded for their discoveries of “how cells sense and adapt to oxygen availability,” the Nobel Committee announced today.

The Karolinska Institute said, the discoveries made by them “have fundamental importance for physiology and have paved the way for promising new strategies to fight anemia, cancer and many other diseases.”

The trio — Kaelin and Semenza are Americans, and Ratcliffe is British — will share equally the 9 million kronor ($918,000) cash award.

It is the 110th prize in the category that has been awarded since 1901.

Kaelin works at Harvard, Semenza at Johns Hopkins University and Ratcliffe is at the Francis Crick Institute in Britain.

In announcing the prize, the Nobel Committee said the work by the three laureates has “greatly expanded our knowledge of how physiological response makes life possible.”

The Committee said that Semenza, Ratcliffe and Kaelin found “the molecular switch for how to adapt” when oxygen levels in the body vary, noting that the most fundamental job for cells is to convert oxygen to food and that cells and tissues constantly experience changes in oxygen availability.

The announcement kicked off Nobel week. The Nobel Physics prize is handed out Tuesday and the following day is the chemistry prize.

This year’s double-header Literature Prizes — one each for 2018 and 2019 — will be awarded Thursday and the Peace Prize will be announced on Friday.

The economics prize will be awarded on Oct. 14.

The 2018 literature prize was suspended after a scandal rocked the Swedish Academy. The body plans to award it this year, along with announcing the 2019 laureate.

Prize founder Alfred Nobel — a Swedish industrialist and the inventor of dynamite — decided the physics, chemistry, medicine and literature prizes should be awarded in Stockholm, and the peace prize in Oslo.

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